Tuesday, December 6, 2011

Jawapan Tutorial DD Pulmonary

Type of Particle
Volume of water dispensed/used in each stages (ml)
Inhaler
L-shape conducting portion
stage 1
stage 2
stage 3
stage 4
stage 5
A
100
100
20
20
20
20
20
B
100
100
20
20
20
20
20








Type of Particle
Concentration of model compounds (µg/ml)
Inhaler
L-shape conducting portion
stage 1
stage 2
stage 3
stage 4
stage 5
A
20
55
15
12
10
8
4.5
B
25
75
22
18.5
17
14.5
6.5

total mass

cumulative mass
cumulative fraction

1. re-arrange the table by adding the cut-off size column





Particle A
 da = 3.85



L-portion Throat





cut-off size
Total mass
cumulative mass
cum.fraction
Stage 5
<1.7
90
90
9.1
Stage 4
1.7
160
250
25.3
Stage 3
3.1
200
450
45.5
Stage 2
6.8
240
690
69.7
Stage 1
13
300
990
100.0









normally ignore but get the value after extrapolation
MMAD = 3.8  GSD = 3.8/2.2 = 1.7

2. Plot particle cut-off size (x-axis) Vs cum. Fraction (Y-axis) on log-probability paper

Particle B
da= 3.79



L-portion Throat





cut-off size
Total mass
cumulative mass
cum.fraction
Stage 5
<1.7
130
130
8.3
Stage 4
1.7
290
420
26.8
Stage 3
3.1
340
760
48.4
Stage 2
6.8
370
1130
72.0
Stage 1
13
440
1570
100.0


MMAD =  3.2
GSD = 3.2/1.7 = 1.8



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